Fertility Statistics in use Today are 300 Years Old

Most women over the age of 25 will be familiar with those concerned looks from older relatives followed up by a whispered: "Isn't it about time you started thinking of having a baby?" But what if much of what we have been led to believe about the impact of age on fertility is not true?

Take this often-cited statistic: one out of three women over the age of 35 will not have conceived after a year of trying.  Jean Twenge, a psychologist at San Diego State University, was 34, recently remarried, and looking to start a family, when she heard it from her doctor.
"That was very frightening to me, as it is to many women who are in their 30s," she says.

Confronted with those odds, she wanted to find out where the statistic had come from. And she discovered something quite amazing.
"The data on which that statistic is based is from 1700s France. They put together all these church birth records and then came up with these statistics about how likely it was someone would get pregnant after certain ages."

These are women who had no access to modern healthcare, nutrition or even electricity. Why would any researcher think they can tell us something useful about modern-day fertility?

Well, actually, they do have one big advantage. They weren't using effective methods of birth control.

"I can empathize slightly with the researchers in this area," says Twenge, who traced the source of the data as she researched her book, An Impatient Woman's Guide to Getting Pregnant. "It is difficult to draw conclusions about age and fertility from modern populations where birth control is widely used."

But there are some studies which have looked at modern couples, and these do paint a rather different picture.

The most widely cited is a paper by David Dunson published in 2004,  which found that 82% of women aged between 35 and 39 fell pregnant within a year. That's significantly better than the two-thirds chance drawn from the 300-year-old birth records.  But can we be confident it's more accurate?

 

  A graph based on 17th-19thC birth records still features in the "Figures and Tables" section of the 2013 Nice fertility guideline

It was a single study undertaken relatively recently of about 780 women, in seven different European centres. The important point about that was that these were women who were trying to conceive.
The main problem with the historic data is that the women may not have been trying to conceive.
Indeed, they may have been actively trying to avoid becoming pregnant. They may not even have had intercourse.

There's no doubt that intercourse becomes less frequent the older the couple are. And in the 1700s, people aged more quickly than today.

Another finding of the Dunson study was that, while fertility declines with age, it does not appear to do so as quickly as we have been led to believe.  Among women aged 27-34, the study showed that 86% will have conceived within a year of trying. So the 82% figure for women aged 35 to 39 is only a little lower.

Improving odds

2004: With regular unprotected sexual intercourse, 94% of fertile women aged 35 years, and 77% of those aged 38 years, will conceive after three years of trying.

 

 2013: Over 80% of couples in the general population will conceive within one year if the woman is aged under 40 years and they do not use contraception and have regular sexual intercourse.

 

After that, the picture becomes a little less clear.

It would appear from the limited and poor quality data that the rate falls significantly at 40. But as we know from some notable celebrity cases, it is not impossible to get pregnant in the early or indeed late 40s. And, apparently, there is evidence that female fertility is improving.

The latest update of the guideline on fertility recognizes that the chances of women naturally conceiving at the age of 40 are much higher now than they were when the original guideline was written [in 2004].

 

But what about the risk of chromosomal abnormalities, such as Down's syndrome?  The chance of any chromosomal abnormality at the age of 20 is one in 500. That increases to one in 400 at the age of 30, and one in 60-70 at age 40.

Down's syndrome

• Caused by extra copy of chromosome 21 in a baby's cells - not known what causes this
• Chance of having a baby with Down's syndrome increases with age, but can be born to mothers of all ages
• About 6,000 babies born with the condition each year in the US

So while it's harder for older women to get pregnant, and the chance of a chromosomally abnormal child increases, these risks do not increase as sharply as feared - except perhaps for those trying IVF or artificial insemination.
"Those statistics are more discouraging for older women," explains Twenge. "The chances of success  in IVF between your early 30s and your late 30s is lower than success with natural conception."

Similarly with artificial insemination - the data shows that the success rates just are not as high as natural conception rates and can differ by as much as 20 percentage points. But many fertility problems that women over 30 experience have nothing to do with age. Had they tried to conceive in their 20s, they would have also faced difficulties.

The fact of the matter seems to be, the best way to have a baby is either in bed or by the fireside on the hearth rug with a  bottle of wine and romantic music. Works for me.